A cancer vaccine platform at the cutting edge of viral immunotherapy

Disruptive technology engineered for lasting efficacy

Vaxalto Biotherapeutics is a pre-clinical stage biotechnology company focused on the development and commercialization of novel engineered immunotherapeutic oncolytic viruses. Our cancer vaccine platform leverages synergy between a novel oncolytic virus and a novel immunomodulator to fight tumors at multiple points of intervention, including viral oncolysis, direct modification of the tumor microenvironment, and systemic immune response to achieve lasting cancer eradication.

Oncolytic viruses with compelling clinical potential

Our approach builds upon decades of scientific research on viruses, vaccines, immunology and cancer by its scientific founders. Our lead product candidate has shown exceptional therapeutic response as single agent therapy in preclinical studies. The platform’s versatility offers the possibility to treat a variety of human cancers as well as emerging pathogens for additional clinical impact and growth opportunities.

OUR TEAM

Leadership

Vaxalto Biotherapeutics was founded by a team of globally recognized scientists from the Icahn School of Medicine at Mount Sinai, New York, with a track record of success in discovering and developing technologies for vaccines and oncolytic virus-based therapeutics.

Scientific Advisory Board

Adolfo García-Sastre, PhD
Director, Global Health and Emerging Pathogens Institute at Mount Sinaii
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Adolfo García-Sastre, PhD
Director, Global Health and Emerging Pathogens Institute at Mount Sinaii
Dr. García-Sastre is a global leader in research on viral pathogens and vaccines. His laboratory focuses on the molecular biology of influenza viruses and other negative strand RNA viruses. His lab pioneered reverse genetic techniques that enabled a generation of recombinant viruses, and he has made major contributions to the influenza virus field. His research has resulted in more than 480 scientific publications and numerous patents. He brings more than two decades of experience in virology, immunology, and vaccines to the Vaxalto team. A long-standing partnership between Dr. Garcia-Sastre and Dr. Palese led to the development of an influenza vaccine and oncolytic viral immunotherapies. In addition to his roles at Mount Sinai, Dr. García-Sastre is the director of the Center for Research on Influenza Pathogenesis, one of the National Centers of Excellence for Influenza Research and Surveillance. He has also served as the President of the International Society for Vaccines, and he is an elected member of the National Academy of Sciences, among many other honors and accomplishments.
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Mihaela Skobe, PhD
Director, Laboratory for Metastasis and Lymphatic Research at Mount Sinai
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Mihaela Skobe, PhD
Director, Laboratory for Metastasis and Lymphatic Research at Mount Sinai
Dr. Skobe is a leading expert in cancer and vascular biology. Research in her laboratory is focused on cancer metastasis, tumor microenvironment, and lymphangiogenesis. She has pioneered the field of tumor lymphangiogenesis, and has made major contributions to research of Vascular Endothelial Growth Factors (VEGFs), including demonstrating the effectiveness of VEGFR-3 inhibition in blocking metastasis. Her discoveries have drawn major attention to the importance of lymphatic vasculature in cancer, a unique area of expertise that she brings to her work at Vaxalto. Dr. Skobe has been elected chair-person of the prestigious Gordon Research Conference on Lymphatic Biology and Pathology, and she received accolades from the Lymphatic Research Foundation for her exceptional contributions to the field, among other distinguished awards.
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Peter Palese, PhD
Chairman, Department of Microbiology at Mount Sinai
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Peter Palese, PhD
Chairman, Department of Microbiology at Mount Sinai
Dr. Palese is a global leader in the fields of infectious viral diseases and vaccines. Dr. Palese’s research focuses on molecular biology of viruses and host-virus interactions, with particular emphasis on the study of RNA viruses including influenza, paramyxo, and corona (SARS) viruses. Research in the Palese Laboratory has led to the development of influenza vaccines, a Covid-19 vaccine, and an NDV-based oncolytic virus. Dr. Palese brings a robust expertise in viruses and vaccine development to his work at Vaxalto. His long list of professional accolades include the Inventor of the Year Award from the Icahn School of Mount Sinai, the IHV Lifetime Achievement Award for Scientific Contributions from the Institute of Human Virology, and the Drexel Prize in Translational Medicine, among others. Dr. Palese is an elected member of the National Academy of Sciences.
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Management Team

Harry L. Crosby
Founder and Chairman
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Harry L. Crosby
Founder and Chairman
Harry L. Crosby has over three decades of experience in investment banking and private equity. He began his career at Lehman Brothers focused in private equity investing, became managing director at Credit Suisse Financial Sponsors group, and led the financial sponsors group for North America at Merrill Lynch. He is a partner in a leading New York based private equity firm. Mr. Crosby has had broad experience in the health care services industry as both advisor and investor and is the principal investor in Vaxalto Biotherapeutics.
Matthew Meyer
Chief Business Advisor
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Matthew Meyer
Chief Business Advisor
Matthew J. Meyer is chief client corporate development advisor at Wilson Sonsini Goodrich & Rosati, where he leads the firm's life science business advisory practice. Matthew is a seasoned biotech executive and attorney with an extensive track record of success in business roles of increasing responsibility across biopharma, medtech, and precision medicine companies, including Pfizer, Novartis, Myriad and CareDx. At Vaxalto, Matthew leverages this experience to support the buildout, financing, strategy, and growth/scale-up of the company.

Ready to seek partners

Contact our team to learn more about our science and discover exciting partnership opportunities.

CONTACT US